MSM Benefits, Dosage, Side Effects

Methylsulfonylmethane is a nutrient that helps with the body’s absorption of cholesterol.

MSM is a supplement that helps with the methylation cycle. It helps to detoxify the body, and it has many benefits.

MSM liquid eye drops may also be used to make ocular membranes more permeable, soften tissues in the eyes, reduce pressure, heal damaged membranes, and make it easier for the eyes to absorb nutrients, according to the Natural Eye Care website.

Skin irritations such as rosacea, allergic responses, varicose veins, and hemorrhoids may be treated with gel, lotion, or cream formulations applied to the skin.

Always verify the proper chemical compound name “MSM (methylsulfonylmethane)” before purchasing MSM from a reliable source.

Many MSM pills include synthetic byproducts and fillers, so keep that in mind. Instead, look for an organic brand that claims to offer “100% organically derived MSM.”


1. Relieves joint pain and osteoarthritis

MSM has been shown to reduce joint inflammation, enhance flexibility, and repair collagen formation in studies. In addition, it may aid in the formation of connective tissue and the healing of joints, tendons, and ligaments.

This is why it’s often used locally to the skin and taken orally as part of an arthritis diet and supplements regimen for pain or osteoarthritis/degenerative joint condition. When people with arthritis, joint pain, stiffness, knee/back difficulties, and a restricted range of motion take an MSM supplement, research indicates that their symptoms improve and their quality of life improves.

MSM pills may aid in treating arthritis by assisting the body in the formation of new joint and muscle tissue while also reducing inflammatory reactions that cause swelling and stiffness. Sulfur also affects the immune system and helps cells function normally.

Sulfur is required for our cells to eliminate various waste products and excess fluids that may build up and cause swelling and pain.

A 12-week scientific investigation comparing the benefits of MSM supplements on joint pain in 118 individuals with osteoarthritis (such as the knee) revealed that MSM supplements resulted in higher improvements in pain, edema, and joint mobility when compared to a placebo. MSM pills were given three times a day in 500-milligram dosages, coupled with glucosamine (also taken in 500-milligram doses three times daily).

They both seem to lower inflammation and pain intensity in the majority of persons without creating negative effects. This implies that MSM is an effective natural arthritis therapy, particularly when paired with glucosamine and chondroitin.

If you just take one of these supplements, some studies have suggested that MSM may be more effective than glucosamine.

2. Helps with Digestive Issues

MSM may assist in repairing the lining of the digestive system and reduce inflammatory responses in the body as a result of food allergies.

It may also help cure leaky gut syndrome by preventing particles from seeping out of the stomach via tiny junction holes and into the bloodstream, where they can cause an inflammatory reaction. This is partly due to the sulfur in MSM supplements, which is necessary for digestion.

According to research, MSM pills may also aid in treating hemorrhoids. Hemorrhoids may be treated with a gel combining MSM and tea tree oil to relieve discomfort and swelling (swollen blood vessels of the rectum that make it hard to go to the bathroom without pain or bleeding).

3. Assists with Skin Conditions

According to some studies, using a topical cream combining MSM and silymarin may help reduce inflammation that causes rosacea, skin pigmentation, allergies, and poor wound healing. Because MSM reduces inflammation, it may help improve skin tone, reduce redness, ease sensitivity, and treat other rosacea symptoms.

People also take it to maintain a young look, even though it hasn’t been established in much research. In addition, it seems to help prevent wrinkles, scar development, dark spots, and sun damage.

I’m not sure how this is feasible. Collagen is what keeps skin from becoming sagging, wrinkled, cracked, and dry, and it’s required for collagen creation.

Because sulfur is essential for synthesizing these “youthful” chemicals, taking an MSM supplement may help us retain valuable collagen and keratin. Unfortunately, as we age, we lose collagen and good tissue, which is why our skin tone and suppleness deteriorate.

When you combine MSM with other antioxidants like vitamin C, vitamin E, and vitamin A, which help produce new, healthy skin cells, you may obtain even better benefits.

4. Reduces muscle pain and spasms

Suppose you’re a frequent exerciser who suffers from muscular soreness. In that case, there’s some good news: MSM may work as a natural painkiller, preventing and treating muscular aches and pains, throbbing, and swelling while also enhancing range of motion and mobility, according to research.

It has been proven to aid muscle recovery after exercise, injuries, and even operations, according to 2017 research, and it seems to be most useful when taken in concert with other anti-inflammatories. Because it helps prevent some byproducts (like lactic acid) that contribute to the sense of soreness, inflexibility, discomfort, and stiffness, taking MSM supplements has been linked to improved immune function, quicker healing, and decreased pain.

In addition, research published in The Journal of Sports Medicine and Physical Fitness demonstrated that taking MSM for only ten days reduced muscle injury by increasing antioxidant capacity.

MSM works by preventing muscular discomfort and injury. It all comes down to sulfur’s function in the body, mostly stored in the tissues that make up our muscles and joints.

It aids in the repair of our muscles’ tough fibrous tissue cells, which are broken down during exercise, preventing them from swelling for lengthy periods of time.

It may also improve the flexibility and permeability of cell walls inside muscles, allowing nutrients to travel more freely through the tissues, allowing for quicker repair work, and removing lactic acid, which provides the “burning” sensation after exercise. As a consequence, recuperation time is decreased, as is pressure, pain, and cramping.

5. It promotes hair growth

Do you have thinning or balding hair as you grow older? Good news: MSM has been found to help increase collagen and keratin levels, two essential elements for new hair strands (and rebuild strong nails and skin cells).

Collagen and keratin are common ingredients in hair products and treatments because they provide hair with strength, resilience, a “healthy” appearance, and the capacity to reverse hair thinning.

6. Assists the body in adjusting to stress

Have you heard of “adaptogen herbs” or supplements that assist the body in regulating how it responds to stress? MSM acts similarly, as it improves our capacity to repair and recover from physical activity, stressful situations, injuries, and even surgery.

“MSM seems to limit the production of inflammatory chemicals in response to exercise,” according to a 2016 research, “allowing cells still to mount an adequate response to an extra stimulus.”

Is MSM putting you to sleep? No, it may really make you feel more energized and less tired.

It seems to minimize muscle damage and other stress signs when taken before exercise, such as jogging. It may also help with weariness from exercise and stressful situations and maintain a positive attitude, energy levels, and regular digestion.

7. Can Assist in the Reduction of Allergies

This supplement may effectively control allergic responses since studies suggest it may help reduce inflammation and reduce the production of cytokines and prostaglandins.

According to research published in the Journal of Alternative and Complementary Medicine, it may help alleviate the symptoms of allergic rhinitis, including itching, congestion, shortness of breath, sneezing, and coughing.


MSM is used to treat a variety of ailments, including:

  • joint discomfort that persists (osteoarthritis, joint inflammation, rheumatoid arthritis)
  • autoimmune diseases and leaky gut syndrome
  • Osteoporosis and the risk of bone fractures
  • bursitis, tendonitis, scar tissue formation, and other musculoskeletal aches and problems
  • Asthma and allergies
  • Infections with yeast
  • cramping in the muscles
  • indigestion, constipation, ulcers, disturbed stomach
  • Symptoms of PMS (cramps, headaches, water retention, indigestion)
  • Stretch marks are visible scars on the skin.
  • hair loss
  • Wrinkles, sunburns (it provides some protection against UV light/windburn), wounds, cuts, and skin abrasions are all common skin issues.
  • infection of the eyes
  • Circulation issues
  • blood pressure that is too high
  • fatigue
  • Infections in the mouth, toothaches, and gum disease/periodontal disease

MSM’s most well-known applications include functioning as an anti-atherosclerotic (preventing artery hardening/thickening), chemo-preventative chemical, and natural anti-inflammatory.

MSM seems to aid the body’s natural, free radical-scavenging abilities, lowering oxidative stress and the many disorders that accompany it.

It works as an anti-inflammatory because it inhibits the production of pro-inflammatory mediators and suppresses the immune system’s damaging signals that may damage the whole body.

MSM Supplements and Their Effects

MSM supplements provide the body with additional sulfur for the production of methionine, which aids in critical internal functions such as the production of other chemicals, the formation of connective tissue, the metabolism of meals, and the absorption of nutrients for energy.

Sulfur is present in all of our bodies at all times, but it might decrease as we age, when we’re stressed, or if we consume a low-nutrient diet regularly. The amino acids methionine and cysteine are the most common dietary sources of sulfur.

According to studies, they are not usually eaten in sufficient quantities to fulfill sulfur needs.

Pure MSM is naturally present in humans (and animals) adrenal cortex, which is a portion of our hormonal system that helps control our reaction to stimuli. It’s also found in our cerebral spinal fluid, where it’s utilized to maintain correct connective tissue structure.

One of the most noteworthy benefits of MSM supplements is that they aid in the speedy healing and “detoxification” of the body by enhancing the flow of substances into and out of our cells. MSM effectively makes cells more permeable, allowing built-up minerals (such as calcium) to be released, as well as heavy metals, waste, and poisons, while also allowing nutrients and water to enter.

This keeps us hydrated while also reducing inflammation, which is at the foundation of most disorders. According to research, MSM also boosts the body’s antioxidant properties, slows or prevents leaking from wounded cells, and scavenges hydroxyl free radicals.

Sulfur in MSM is also necessary to form glutathione, a “master antioxidant” and vital detoxifying agent.


How much MSM do you need or recommend? Because there are no established symptoms of sulfur insufficiency mentioned in medical literature, the FDA does not recognize a suggested dietary intake for an MSM supplement or sulfur (which it includes).

As a result, the dose you should take is determined by what you’re utilizing MSM for and your present health.

The beginning dosage for treating osteoarthritis is usually 500 milligrams of MSM, given two to three times daily. One research, for example, provided participants 1,200 mg each day for 12 weeks.

Other studies have shown that taking up to three to six grams of MSM per day (usually split into three doses) is safe and well-tolerated.

Is MSM safe for dogs to consume?

According to Dogs Naturally Magazine, it may be given to dogs to aid with joint discomfort, injuries, and inflammation. However, avoid feeding any pet a product that includes sweeteners and tastes like xylitol, lethal to dogs.

A “therapeutic dose” of 50 to 100 mg MSM per 10 pounds of body weight is indicated for dogs.

Side Effects and Risks

Because MSM is fully natural and already exists in the human body, it seems to be well tolerated. So far, there haven’t been many major adverse effects of MSM recorded, but there haven’t been many big, well-controlled human studies looking at its long-term consequences either.

Based on the most reputable studies conducted so far on this supplement — such as a 2006 pilot study that analyzed the effects of 6,000 milligrams of MSM taken daily by patients with osteoarthritis — it effectively helps improve pain and physical function without any major side effects, according to the Arthritis Foundation.

However, it may cause minor adverse effects in some individuals, including indigestion, stomach trouble, diarrhea, and skin and eye irritation. It’s also not recommended for persons taking blood thinners because of the risk of adverse effects on the heart and cardiovascular system.

If you’re pregnant, see your doctor before taking it regularly.

Last Thoughts

  • What exactly is MSM? Methylsulfonylmethane is a supplement that stands for methylsulfonylmethane (or dimethyl sulfone or DMSO2). Supplies biologically active sulfur, the body’s fourth most abundant mineral and is required for daily vital physical activities.
  • It’s known as the “wonder supplement” since it’s been proved to reduce inflammation, combat stress and discomfort, boost immunity, and boost energy.
  • Acting as an anti-atherosclerotic (preventing the hardening/thickening of arteries), chemo-preventative ingredient, and natural anti-inflammatory are three of the most well-known purposes for this supplement.
  • MSM advantages include curing osteoarthritis and joint pain, reducing digestive issues such as leaky gut syndrome, mending skin, treating skin issues such as rosacea, allergies, and wounds, lowering muscular discomfort and spasms, and restoring hair growth and assisting the body in adapting to stress.
  • MSM has a reduced risk of adverse effects since it is often well tolerated. Some users, however, may develop stomach problems.

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